The ‘City that Never Sleeps’ beckons — renowned museums and sites galore by day; the glittering sophistication of clubs, theaters and restaurants by night. Explore Chinatown, Greenwich Village, the United Nations, Central Park’s Museum Mile and Wall Street’s towering steel and glass monuments to commerce, then hop into a cab for an afternoon of world-class shopping along Park and Fifth Avenues.

Situated on Spain’s Costa del Sol, Malaga is the region’s capital and a popular holiday destination. The city is also renowned as the birthplace of Pablo Picasso, whose works can be seen in the fairly new Museo Picasso housed in the Palacio de Buenavista. And connoisseurs can imbibe in the sweet Malaga dessert wines that come from the hilly vineyards just outside of town. This is a pleasant town to explore and also serves as a popular starting point for excursions to splendid Granada and the famed Alhambra, located inland at the foothills of the Sierra Nevada.

Valencia was established by the Greeks and later occupied by the Carthaginians, Romans, Visigoths and Arabs. A 15th century artistic movement here gave the world spectacular paintings, sculptures, and jewels. Today a “City of Arts and Sciences,” Valencia offers visitors remarkable samples of modern architecture, alongside such notable classics as the 13th century Cathedral and Chapel of the Holy Chalice. Built on the site of a mosque which was originally a Roman temple the Chapel contains the chalice which legend says was used by Christ at the Last Supper. For a more historic view, take in the Quart Towers, a former gate of the medieval wall, built in 1444; and Serranos Towers, a former prison surrounded by a moat and built around 1391.

One of Europe’s most visually stunning cities, Barcelona balances the medieval intimacy of its Gothic Quarter with the grace and distinction of the wide boulevards in the Moderniste Eixample. It was the home of architect Antoni Gaudí, whose Sagrada Familia Cathedral, Park Güell and Casa Milà are the most profound statements of Modernisme. View the splendid works at the Picasso Museum and the Miro Foundation, or discover Barcelona’s passionate ambiance at a flamenco show.