Via di S. Teodoro, 48, 00186 Roma RM, Italy

Nestled amid gardens, this refined hotel in a converted, long-standing convent is a 12-minute walk from the nearest subway stop, and 1 km from the Roman Forum, a collection of ancient Roman remains. Modern rooms with wood accents and high ceilings feature Wi-Fi, flat-screen TVs and minibars. Upgraded room and suites add whirlpool tubs. Suites, some bi-level, have separate living areas. Room service is available. A breakfast buffet is served in a polished restaurant with vaulted ceilings and garden terrace seating; there's also a lobby bar. Other amenities include conference facilities.

Via Vittorio Veneto, 62, 00187 Roma RM, Italy

V. Giulia, 62, 00186 Roma RM, Italy

Set in a traditional building with stone foundations, this sleek hotel is 15 minutes' walk from the Pantheon and 1.8 km from the Sistine Chapel. Contemporary rooms with wood floors and marble bathrooms offer free Wi-Fi, flat-screen TVs and iPod docks, as well as minibars, and tea and coffeemakers. Some offer retro or reproduction artwork. Upgraded rooms include complimentary minibars, and suites add living areas with pull-out sofas. A free breakfast buffet is served in a bright bistro. Other amenities include a wine bar and a restaurant with a seasonal rooftop terrace. There's also a spa with a hot tub, a sauna and a fitness room.

Via Giuseppe Mazzini, 57, 56125 Pisa PI, Italy

Set in a traditional Tuscan building with wood shutters, this polished hotel is an 8-minute walk from Pisa Centrale train station, and 2 km from both the Leaning Tower of Pisa and the Cattedrale di Pisa. The warm, understated rooms feature free Wi-Fi, flat-screen TVs, minifridges, and tea and coffeemaking facilities. Room service is available. Free amenities include continental breakfast and an area shuttle. There's also a relaxed bar, a garden terrace and a reading room. Parking and bike rentals are available for a fee.

Piazza della Stazione, 2, 56125 Pisa PI, Italy

This modern hotel across the street from Pisa Centrale train station is 2 km from both the Leaning Tower of Pisa and from the Cattedrale di Pisa. Informal rooms come with 24/7 room service, minibars, free Wi-Fi and satellite/cable TV. Upgraded rooms add balconies. Suites offer pull-out sofas. Breakfast and parking are available. Other amenities include a 24-hour snack shop and meeting rooms. A restaurant is available for events.

Via Sant'Apollonia, 35/37, 56126 Pisa PI, Italy

Housed in 2 buildings, one dating from the 11th century, this low-key hotel is 7-minute walk from the Leaning Tower of Pisa and a 10-minute walk from the Pisa Baptistry. Casual rooms with murals feature Wi-Fi, flat-screen TVs and minibars. Upgraded rooms add antique-style furnishings, and some have whirlpool tubs. A breakfast buffet and parking are available. There's a laid-back dining room. There's also a furnished terrace with views of the tower.

Via Solferino, 6, 50123 Firenze FI, Italy

Via Ventisette Aprile, 52/R, 50129 Firenze FI, Italy

A 6-minute walk from Galleria dell'Accademia, this elegant hotel in a classic stone building is 11 minutes' walk from Florence Cathedral and 17 minutes' walk from Ponte Vecchio bridge. Featuring Wi-Fi, the warm, individually designed rooms with vintage Florentine decor offer flat-screen TVs, minifridges and desks. Some have canopy beds, sofabeds, and/or tea and coffeemakers. A breakfast buffet is served in a relaxed dining room or in-room. There's also a lounge with a wood-beamed ceiling.

Via de' Cerretani, 68, 50123 Firenze FI, Italy

A 4-minute walk from the Cathedral of Santa Maria del Fiore, this polished hotel in a 17th-century building is 1 km both from Renaissance art in the Uffizi Gallery and from medieval Ponte Vecchio. Refined rooms offer free Wi-Fi, flat-screen TVs and minibars, plus tea and coffeemaking equipment. They also include marble bathrooms and designer toiletries. Suites add separate living areas. Room service is available 24/7. Amenities include a business center and a sophisticated bar offering traditional Tuscan cuisine. A breakfast buffet is available for a fee.

Campo San Stae, 2070, 30135 Venezia VE, Italy

Adjacent to the San Stae vaporetto stop on the Grand Canal, this elegant 16th-century palace-turned-hotel is a 9-minute walk from the Rialto Bridge. Refined rooms feature traditional terrazzo or parquet floors, and stone or marble bathrooms. All provide Wi-Fi, flat-screen TVs and safes; some have canal views. Suites add living space, balconies and/or whirlpool tubs. Individual details include sloped wood-beamed ceilings, original 16th-century furniture and ornate chandeliers. Room service is available. Breakfast is available. Amenities consist of a polished bar and lounge areas.

Riva degli Schiavoni, 4149, 30122 Venezia VE, Italy

Offering Venetian Lagoon views, this premium hotel is an 8-minute walk from Saint Mark's Basilica, a 9-minute walk from Piazza San Marco and 2 km from the Grand Canal. Ornate rooms and suites with plush decor and antique furniture come with seating areas. Some include murals, 4-poster beds, fireplaces and/or lagoon views. There's a suite with a rooftop terrace; another features a hammam. Wi-Fi is available. Breakfast is available. There's a renowned restaurant, a garden terrace, and a refined cocktail bar that hosts seasonal tea ceremonies. A gallery has a collection of antiques.

Santa Croce 245, Giardini Papadopoli, 30135 Venezia VE, Italy

Set beside a canal, this upscale, chic hotel is a 2-minute walk from the nearest vaporetto stop and 1.8 km from the iconic, 12th-century Piazza San Marco. Elegant rooms styled in luxe, 18th-century Venetian decor include free Wi-Fi, flat-screen TVs, minibars and work desks. Suites are available, and room service is also offered. Amenities include an elegant restaurant with exposed stone walls and a glass-enclosed dining room, plus a refined bar and a winter garden.

Piazza Luigi di Savoia, 20, 20124 Milano MI, Italy

This upscale, cosmopolitan hotel is a 3-minute walk from both Milano Central train station and Caiazzo metro station. It's also 3 km from the fashion and jewelry shopping of Via Monte Napoleone. Offering free Wi-Fi, the warm, modern rooms and suites also have flat-screen TVs, tea and coffeemaking facilities, and minibars. Suites add separate seating areas. Room service is available. A complimentary breakfast buffet is served in the hotel's stylish black-and-white restaurant. Additional amenities include a bar and a 24-hour fitness room. Parking is also available for a fee.

Via Luigi Galvani, 12, 20124 Milano MI, Italy

This sophisticated hotel is a 3-minute walk from the Centrale metro station, and 3 km from both Sforza Castle and Santa Maria delle Grazie, which houses Leonardo da Vinci's The Last Supper. The warm, traditionally furnished rooms come with Wi-Fi, flat-screen TVs and desks, along with marble bathrooms. Suites feature separate living rooms. Upgraded suites add balconies, and access to a private lounge offering breakfast and refreshments. There are 2 elegant restaurants; one also has a bar. Other amenities include a gym and meeting rooms. Pets are welcome.

Via Melchiorre Gioia, 73, 20124 Milano MI, Italy

Next to a metro station, this upscale hotel is 3 km from high-end shopping on Via Monte Napoleone. It's 4 km from the Duomo di Milano. Chic rooms feature free Wi-Fi, flat-screen TVs and marble bathrooms. Upgraded quarters offer tea and coffeemaking facilities, soaking tubs and rainfall showers; some add balconies. Sleek suites have living rooms. Room service is available. Amenities include an upmarket restaurant/bar with a terrace, as well as a fitness room offering city views. There's also a spa, a sauna and a steam room, plus pool tables, a bowling alley, tennis courts and a jogging track. Parking is available (fee), and pets are welcome.